Polyethylene Glycol-Fusion Repair of Peripheral Nerve Injuries.

Hand Clin · Aug 2024 · Review

Bittner GD, Tuffaha S, Shores JT

Plastic & Reconstructive Surgery, Johns Hopkins University School of Medicine, 4940 Eastern Avenue

Hand & Upper Extremity

SUMMARY — THE REDUCTIONThis review describes polyethylene glycol-fusion technology for peripheral nerve repair, noting it restores axonal continuity and reduces muscle atrophy, with promising safety in early clinical trials of digital nerve repair.
Abstract, as published

Axons successfully repaired with polyethylene glycol (PEG) fusion tecnology restored axonal continuity thereby preventing their Wallerian degeneration and minimizing muscle atrophy. PEG fusion studies in animal models and preliminary clinical trials involving patients with digital nerve repair have shown promise for this therapeutic approach. PEG fusion is safe to perform, and given the enormous potential benefits, there is no reason not to explore its therapeutic potential.

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