Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair.

J Bone Joint Surg Am · Feb 19 2025 · Review

Cong T, Morse KW, Sosa BR, Lane JM, Rodeo SA, Greenblatt MB

Hospital for Special Surgery, New York, NY

General Orthopaedics

SUMMARY — THE REDUCTIONThis review describes how skeletal stem cells self-renew, maintain multilineage potential, and express region-specific markers that underlie skeletal homeostasis, pathology, and tissue repair.
Abstract, as published

➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

Read the article: PubMed · Publisher (DOI)

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