Ankle Instability as a Global Concept.

Foot Ankle Clin · Dec 2025 · Review

Vega J, Abdelatif NMN, Guelfi M

MIFAS by GRECMIP, Merignac, France; Casa di Cura Villa Montallegro, Italy

Foot & Ankle

SUMMARY — THE REDUCTIONThis review reframes chronic ankle instability as a 'domino effect' causing intra- and extra-articular changes, emphasizing careful clinical exam and stabilization before treating secondary issues, most of which resolve without surgery.
Abstract, as published

Ankle sprains most commonly injure the superior fascicle of the anterior talofibular ligament, often initiating a cascade of biomechanical changes termed the "domino effect." Chronic ankle instability can lead to both intra-articular and extra-articular alterations, which may become symptomatic, sometimes even without overt instability symptoms. Accurate clinical examination is crucial, as standard imaging may miss ligament injuries. Management of ankle instability is essential before addressing secondary changes. While surgical treatment is recommended after failed conservative therapy, most secondary muscle-tendon issues do not require surgery, and some impingements resolve naturally following stabilization of the ankle joint.

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