Poor mental health in patients with symptomatic osteochondral lesions of the talus.

Bone Joint J · Sep 01 2026 · Recent

Pijnacker JHM, Agyeman-Prempeh NO, Sierevelt IN, Emanuel KS, Amsterdam Ankle Cartilage Team, Broekman B, et al.

Department of Orthopaedic Surgery and Sports Medicine, Amsterdam UMC, Location AMC, The Netherlands

Foot & Ankle Sports Medicine

SUMMARY — THE REDUCTIONThis prospective study found that most patients with symptomatic osteochondral talar lesions have mental health scores as poor as those with mood/anxiety disorders, persisting even after successful treatment, supporting integrated mental health care.
Abstract, as published

AIMS: Osteochondral lesions of the talus (OLT) can cause pain and functional limitations, potentially affecting mental health. This study aimed to compare mental health in patients with OLT to the general Dutch population and individuals with mood or anxiety disorders, and to identify factors associated with mental health in OLT patients.

METHODS: This prospective study included patients with symptomatic OLT prior to treatment. Data for the general population and individuals with mood or anxiety disorders were obtained from the Netherlands Mental Health Survey and Incidence Study-3. Mental health was assessed using the Mental Health Inventory-5 (MHI-5). The primary outcome was the mean difference in MHI-5 between OLT patients and the general population. Multivariate linear regression examined associations between mental health and age, sex, BMI, smoking, lesion characteristics, laterality, and Foot and Ankle Outcome Score (FAOS) pain.

RESULTS: Among the 358 included OLT patients, 87% (311 of 358) scored ≤ 76 on the MHI-5. OLT patients scored significantly lower than the general population (mean difference 20.2 (95% CI 18.9 to 21.5)) and showed similar scores to individuals with a mood or anxiety disorder (mean difference 2.0 (95% CI -0.3 to 4.3)). One and two years after treatment, 79% (170/214) and 78% (134/173) of patients, respectively, scored ≤ 76 on the MHI-5. Multivariate analysis identified smoking (β = -2.6 (95% CI -4.7 to -0.4)) and FAOS pain (β = 0.3 (95% CI 0.1 to 0.3)) significantly associated with MHI-5 scores.

CONCLUSION: Poor mental health is highly prevalent in patients with OLT, with scores substantially lower than the general population and comparable with individuals with mood or anxiety disorders. Smoking and ankle pain were associated with worse mental health. Despite successful long-term clinical outcomes of treatment of OLT, mental health remained poor. These findings underscore the importance of integrating mental health interventions alongside orthopaedic care for patients with OLT.

Featured in the 2026-09-08 issue.

← Dedicated Ankle AP and Long-Leg Radiographs Are Not Interchan…Stress Fractures of the Fifth Metatarsal in Athletes. →

The Reduction is a free email digest of newly published orthopaedic literature — a handful of new papers in the subspecialties you choose, each summarized like this one. Subscribe free or browse the archive.