Classic Papers in Orthopaedic Oncology

Pool built 2026-11-06 · All specialties

These are the 100 most-cited papers published in the Orthopaedic Oncology journals, ranked by lifetime citations (via OpenAlex; retracted papers excluded). The daily digest draws its classic slot from this pool — subscribe to get one with your new articles, or browse the Orthopaedic Oncology archive.

1. Guidelines for the Management of Soft Tissue Sarcomas

   Robert John Grimer, Ian Robert Judson, David Peake et al. — Sarcoma · 2010 · cited 434 times

2. The Molecular Pathogenesis of Osteosarcoma: A Review

   Matthew L. Broadhead, Jonathan C. M. Clark, Damian E. Myers et al. — Sarcoma · 2011 · cited 348 times

3. The Intergroup Rhabdomyosarcoma Study Group (IRSG): Major Lessons From the IRS‐I Through IRS‐IV Studies as Background for the Current IRS‐V Treatment Protocols

   Richard Beverly Raney, Harold M. Maurer, James Robert Anderson et al. — Sarcoma · 2001 · cited 310 times

4. Using Epidemiology and Genomics to Understand Osteosarcoma Etiology

   Sharon A. Savage, Lisa J. Mirabello — Sarcoma · 2011 · cited 301 times

5. The Genetics of Osteosarcoma

   Jeff W. Martin, Jeremy Andrew Squire, Maria Zieleńska — Sarcoma · 2012 · cited 253 times

6. The Classic: A System for the Surgical Staging of Musculoskeletal Sarcoma

   William F. Enneking, Suzanne S. Spanier, Mark A. Goodman — Clin Orthop Relat Res · 2003 · cited 250 times

7. “Malignant” Perivascular Epithelioid Cell Neoplasm: Risk Stratification and Treatment Strategies

   Jonathan Scott Bleeker, J. Fernando Quevedo, Andrew L. Folpe — Sarcoma · 2012 · cited 219 times

8. Liposarcoma: Molecular Genetics and Therapeutics

   Rachel K. Conyers, Sophie Young, David Morgan Thomas — Sarcoma · 2010 · cited 213 times

9. A Pilot Study of Anti-CTLA4 Antibody Ipilimumab in Patients with Synovial Sarcoma

   Robert G. Maki, Achim A. Jungbluth, Sacha Gnjatic et al. — Sarcoma · 2013 · cited 178 times

10. Survival in Malignant Peripheral Nerve Sheath Tumours: A Comparison between Sporadic and Neurofibromatosis Type 1-Associated Tumours

    D. Porter, Vishal Prasad, L. Foster et al. — Sarcoma · 2009 · cited 163 times

11. The role of tumour-associated macrophages in bone metastasis

    Sofia Sousa, Jorma A. Määttä — J Bone Oncol · 2016 · cited 158 times

12. MicroRNA Involvement in Osteosarcoma

    Eisuke Kobayashi, Francis John Hornicek, Zhenfeng Duan — Sarcoma · 2012 · cited 151 times

13. The Role of RUNX2 in Osteosarcoma Oncogenesis

    Jeff W. Martin, Maria Zieleńska, Gary S. Stein et al. — Sarcoma · 2010 · cited 148 times

14. Computer-Assisted Planning and Patient-Specific Instruments for Bone Tumor Resection within the Pelvis: A Series of 11 Patients

    F. Gouin, Laurent Paul, Guillaume Anthony Odri et al. — Sarcoma · 2014 · cited 146 times

15. Risk and clinicopathological features of osteosarcoma metastasis to the lung: A population-based study

    Xiaoyi Huang, Jian Zhao, Jinyi Bai et al. — J Bone Oncol · 2019 · cited 142 times

16. Identification of Differentially Expressed MicroRNAs in Osteosarcoma

    Rishi Ramesh Lulla, Fabrício Falconi Costa, Jared M. Bischof et al. — Sarcoma · 2011 · cited 140 times

17. Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family

    Heinrich Kovar — Sarcoma · 2010 · cited 135 times

18. Quality of Life Implications as a Consequence of Surgery: Limb Salvage, Primary and Secondary Amputation

    Christine Eiser, Anne‐Sophie Darlington, Chris Stride et al. — Sarcoma · 2001 · cited 129 times

19. Clinical Features of Sarcomatoid Carcinoma (Carcinosarcoma) of the Urinary Bladder: Analysis of 221 Cases

    Jue Wang, Fen Wei Wang, Chad A. LaGrange et al. — Sarcoma · 2010 · cited 128 times

20. The role of osteoblasts in bone metastasis

    Penelope Dawn Ottewell — J Bone Oncol · 2016 · cited 124 times

21. Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma

    Patrick P. Lin, Yongxing Wang, Guillermina Lozano — Sarcoma · 2010 · cited 115 times

22. Synovial Chondrosarcoma Arising in Synovial Chondromatosis

    Scott Evans, Michele Boffano, Samena Chaudhry et al. — Sarcoma · 2014 · cited 114 times

23. The Identification of Prognostic Factors and Survival Statistics of Conventional Central Chondrosarcoma

    Sjoerd P. F. T. Nota, Yvonne Braun, Joseph Hasbrouck Schwab et al. — Sarcoma · 2015 · cited 113 times

24. Incidence and consequences of bone metastases in lung cancer patients

    Michael Kuchuk, Christina Addison, Mark J. Clemons et al. — J Bone Oncol · 2013 · cited 112 times

25. Prognostic Factors and Metastatic Patterns in Primary Myxoid/Round-Cell Liposarcoma

    J. Haniball, Vaiyapuri P. Sumathi, Lars‐Gunnar Kindblom et al. — Sarcoma · 2011 · cited 112 times

26. Desmoplastic Small Round Cell Tumor: Current Management and Recent Findings

    Armelle Dufresne, Philippe Alexandre Cassier, Laure Couraud et al. — Sarcoma · 2012 · cited 111 times

27. Should Soft Tissue Sarcomas be Treated at a Specialist Centre?

    Aneel A Bhangu, J. A. S. Beard, Robert John Grimer — Sarcoma · 2004 · cited 110 times

28. Doxorubicin‐Based Chemotherapy for the Palliative Treatment of AdultPatients with Locally Advanced or Metastatic Soft‐Tissue Sarcoma:A Meta‐Analysis and Clinical Practice Guideline

    Vivien H. C. Bramwell, Dale Anderson, Manya L. Charette — Sarcoma · 2000 · cited 110 times

29. The Management of Chondrosarcoma of Bone

    A. Ingrid Eriksson, Alan L. Schiller, Henry J. Mankin — Clin Orthop Relat Res · 1980 · cited 109 times

30. Incidence, consequences and treatment of bone metastases in breast cancer patients—Experience from a single cancer centre

    Iryna Kuchuk, Brian Hutton, Patrícia Moretto et al. — J Bone Oncol · 2013 · cited 108 times

31. FDG PET/CT in Initial Staging of Adult Soft-Tissue Sarcoma

    David Roberge, Siavosh Vakilian, Yazan Z. Alabed et al. — Sarcoma · 2012 · cited 104 times

32. Intensified Adjuvant IFADIC Chemotherapy for Adult Soft Tissue Sarcoma: A Prospective Randomized Feasibility Trial

    T. Brodowicz, Eva Schwameis, Joachim Widder et al. — Sarcoma · 2000 · cited 104 times

33. Benefits and risks of adjuvant treatment with zoledronic acid in stage II/III breast cancer. 10 years follow-up of the AZURE randomized clinical trial (BIG 01/04)

    Robert Edward Coleman, Michelle Collinson, Walter Martin Gregory et al. — J Bone Oncol · 2018 · cited 103 times

34. Overexpression of lncRNA UCA1 promotes osteosarcoma progression and correlates with poor prognosis

    Wu Li, Peng Xie, Wenhui Ruan — J Bone Oncol · 2016 · cited 103 times

35. Solitary Fibrous Tumors and So-Called Hemangiopericytoma

    Nicolas Penel, Eric Yaovi Amela, Gauthier Decanter et al. — Sarcoma · 2012 · cited 103 times

36. SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors

    Christine S. Higham, Seth M. Steinberg, Eva Dombi et al. — Sarcoma · 2017 · cited 100 times

37. Imaging Features of Superficial and Deep Fibromatoses in the Adult Population

    Eric A. Walker, Jonelle M. Petscavage, Pamela L. Brian et al. — Sarcoma · 2012 · cited 100 times

38. Chondrosarcoma: With Updates on Molecular Genetics

    Mi-Jung Kim, Kyung‐Ja Cho, Alberto G. Ayala et al. — Sarcoma · 2011 · cited 97 times

39. Defective Osteogenic Differentiation in the Development of Osteosarcoma

    Eric R. Wagner, Gaurav Aman Luther, Gaohui Zhu et al. — Sarcoma · 2011 · cited 96 times

40. Frequency of Certain Established Risk Factors in Soft Tissue Sarcomas in Adults: A Prospective Descriptive Study of 658 Cases

    Nicolas Penel, Jessica Grosjean, Y. Marie Robin et al. — Sarcoma · 2008 · cited 96 times

41. Stereotactic Body Radiotherapy for Metastatic and Recurrent Ewing Sarcoma and Osteosarcoma

    Lindsay C. Brown, Rachael A. Lester, Michael P. Grams et al. — Sarcoma · 2014 · cited 95 times

42. Osteosarcoma: Evolution of Treatment Paradigms

    Norman Jaffe, Ajay Puri, Hans A. J. Gelderblom — Sarcoma · 2013 · cited 93 times

43. The role of osteoclasts in breast cancer bone metastasis

    François Le Pape, Geoffrey Vargas, Philippe Clézardin — J Bone Oncol · 2016 · cited 91 times

44. At-Risk Populations for Osteosarcoma: The Syndromes and Beyond

    George T. Calvert, Robert Lor Randall, Kevin B. Jones et al. — Sarcoma · 2012 · cited 91 times

45. Ewing′s Sarcoma of the Head and Neck: A Retrospective Analysis of 24 Cases

    Ayman Abdel Kader Allam, Gamal A. El-Husseiny, Yasser Khafaga et al. — Sarcoma · 1999 · cited 90 times

46. Low-Grade Fibromyxoid Sarcoma: Incidence, Treatment Strategy of Metastases, and Clinical Significance of theFUSGene

    Katja Maretty-Nielsen, Steen Bærentzen, Johnny O. Keller et al. — Sarcoma · 2013 · cited 89 times

47. Fluorescence In Situ Hybridization for MDM2 Amplification as a Routine Ancillary Diagnostic Tool for Suspected Well-Differentiated and Dedifferentiated Liposarcomas: Experience at a Tertiary Center

    Khin Thway, Jayson Wang, John G. Swansbury et al. — Sarcoma · 2015 · cited 88 times

48. Characteristics and Patterns of Metastatic Disease from Chordoma

    Victoria A. Young, Kevin M. Curtis, Harry Thomas Temple et al. — Sarcoma · 2015 · cited 88 times

49. MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions

    Chandhanarat Chandhanayingyong, Yuhree Kim, J. Robert Staples et al. — Sarcoma · 2012 · cited 88 times

50. UK Guidelines for the Management of Bone Sarcomas

    Robert John Grimer, Nick A. Athanasou, Craig Gerrand et al. — Sarcoma · 2010 · cited 87 times

51. Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistance

    Helin Feng, Jin Wang, Wei Chen et al. — J Bone Oncol · 2016 · cited 84 times

52. Guidance for the assessment and management of prostate cancer treatment-induced bone loss. A consensus position statement from an expert group

    Janet Elizabeth Brown, Catherine Handforth, Juliet Elizabeth Compston et al. — J Bone Oncol · 2020 · cited 81 times

53. A Cadaveric Comparative Study on the Surgical Accuracy of Freehand, Computer Navigation, and Patient-Specific Instruments in Joint-Preserving Bone Tumor Resections

    Sarah E. Bosma, Kwok Chuen Wong, Laurent Paul et al. — Sarcoma · 2018 · cited 79 times

54. Alveolar Soft Part Sarcoma: A Single-Center 26-Patient Case Series and Review of the Literature

    Koichi Ogura, Yasuo Beppu, Hirokazu Chuman et al. — Sarcoma · 2012 · cited 79 times

55. Spinal Chondrosarcoma: A Review

    Pavlos Katonis, Kalliopi Alpantaki, Konstantinos Michail et al. — Sarcoma · 2011 · cited 79 times

56. Pathobiologic Markers of the Ewing Sarcoma Family of Tumors: State of the Art and Prediction of Behaviour

    Alfredo Pinto, Paul S. Dickman, David M. Parham — Sarcoma · 2010 · cited 79 times

57. Extraskeletal Osteosarcoma: Analysis of Outcome of a Rare Neoplasm

    Martin D. McCarter, Jonathan J. Lewis, Cristina R. Antonescu et al. — Sarcoma · 2000 · cited 79 times

58. Blockade of CCL2 enhances immunotherapeutic effect of anti-PD1 in lung cancer

    Yue Wang, Xiaokai Zhang, Liangliang Yang et al. — J Bone Oncol · 2018 · cited 78 times

59. Surgical Guides (Patient-Specific Instruments) for Pediatric Tibial Bone Sarcoma Resection and Allograft Reconstruction

    Laura Bellanova, Laurent Paul, Pierre‐Louis Docquier — Sarcoma · 2013 · cited 78 times

60. Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre

    Khin Thway, Cyril Fisher — Sarcoma · 2009 · cited 78 times

61. The bone metastasis niche in breast cancer: potential overlap with the haematopoietic stem cell niche in vivo

    Gloria Allocca, Russell Hughes, Ning Wang et al. — J Bone Oncol · 2019 · cited 77 times

62. miRNA-223 is a potential diagnostic and prognostic marker for osteosarcoma

    Junbo Dong, Yilin Liu, Wensheng Liao et al. — J Bone Oncol · 2016 · cited 77 times

63. The role of 18F–NaF PET/CT in metastatic bone disease

    Mine Araz, Gülseren Araş, Ömer Küçük — J Bone Oncol · 2015 · cited 77 times

64. Aneurysmal bone cyst: A review of 65 patients

    Ferdinand Grahneis, Alexander Klein, Andrea Baur‐Melnyk et al. — J Bone Oncol · 2019 · cited 75 times

65. Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016)

    Brigitte C. Widemann, Yao Lu, Denise K. Reinke et al. — Sarcoma · 2019 · cited 74 times

66. The Influence of Elementary Silver Versus Titanium on Osteoblasts Behaviour In Vitro Using Human Osteosarcoma Cell Lines

    Jendrik Hardes, Arne Streitbürger, H. Ahrens et al. — Sarcoma · 2007 · cited 74 times

67. Computer-Assisted Resection and Reconstruction of Pelvic Tumor Sarcoma

    Pierre‐Louis Docquier, Laurent Paul, Olivier Cartiaux et al. — Sarcoma · 2010 · cited 73 times

68. The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets

    Emmanuelle David, Frédéric Blanchard, Marie‐Françoise Heymann et al. — Sarcoma · 2011 · cited 70 times

69. Can Experienced Observers Differentiate between Lipoma and Well-Differentiated Liposarcoma Using Only MRI?

    Patrick W. O’Donnell, Anthony Michael Griffin, William C. Eward et al. — Sarcoma · 2013 · cited 69 times

70. Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023)

    AeRang Kim, Yao Lu, Scott H. Okuno et al. — Sarcoma · 2020 · cited 68 times

71. Giant Cell Tumors of the Axial Skeleton

    Maurice Balke, Marcel P. Henrichs, Georg Gosheger et al. — Sarcoma · 2012 · cited 68 times

72. Intercalary Reconstructions with Vascularised Fibula and Allograft after Tumour Resection in the Lower Limb

    Katharina Rabitsch, Werner Maurer-Ertl, Ulrike Michaela Pirker-Frühauf et al. — Sarcoma · 2013 · cited 67 times

73. Delays in Referral of Soft Tissue Sarcomas

    Graham David Johnson, G. Smith, Asterios Dramis et al. — Sarcoma · 2008 · cited 67 times

74. Soft Tissue Tumours of the Retroperitoneum

    J. F. Graadt van Roggen, Pancras C.W. Hogendoorn — Sarcoma · 2000 · cited 67 times

75. EWSR1-NFATC2 and FUS-NFATC2 Gene Fusion-Associated Mesenchymal Tumors: Clinicopathologic Correlation and Literature Review

    Beata Bode‐Lesniewska, Christine Fritz, Gerhard Ulrich Exner et al. — Sarcoma · 2019 · cited 66 times

76. Clinical Activity and Tolerability of a 14-Day Infusional Ifosfamide Schedule in Soft-Tissue Sarcoma

    Juan Martín-Liberal, Salma Moona Alam, Anastasia Constantinidou et al. — Sarcoma · 2013 · cited 66 times

77. Application of 3D-printed PEEK scapula prosthesis in the treatment of scapular benign fibrous histiocytoma: A case report

    Dong Liu, Jun Fu, Hongbin Fan et al. — J Bone Oncol · 2018 · cited 65 times

78. Radiomics and Machine Learning Differentiate Soft-Tissue Lipoma and Liposarcoma Better than Musculoskeletal Radiologists

    Ieva Malinauskaitė, Jérémy Hofmeister, Simon Burgermeister et al. — Sarcoma · 2020 · cited 65 times

79. Molecular Characterization of Putative Chordoma Cell Lines

    Silke Brüderlein, Joshua Sommer, Paul S. Meltzer et al. — Sarcoma · 2010 · cited 65 times

80. The Use of Massive Endoprostheses for the Treatment of Bone Metastases

    Derek Howard Park, Parag Jaiswal, Wisam Al-Hakim et al. — Sarcoma · 2007 · cited 65 times

81. Quality of life after palliative radiotherapy in bone metastases: A literature review

    Rachel E McDonald, Edward Chow, Leigha Rowbottom et al. — J Bone Oncol · 2014 · cited 64 times

82. Quality of Life and Utility in Patients with Metastatic Soft Tissue and Bone Sarcoma: The Sarcoma Treatment and Burden of Illness in North America and Europe (SABINE) Study

    Peter Reichardt, Michael Gordon Leahy, Xavier García del Muro et al. — Sarcoma · 2012 · cited 64 times

83. Follow up after Primary Treatment of Soft Tissue Sarcoma: A Survey of Current Practice in the United Kingdom

    Craig Gerrand, Lucinda Jane Billingham, Penella J. Woll et al. — Sarcoma · 2007 · cited 64 times

84. Radiomics signature extracted from diffusion-weighted magnetic resonance imaging predicts outcomes in osteosarcoma

    Shuliang Zhao, Yi Su, Jinghao Duan et al. — J Bone Oncol · 2019 · cited 63 times

85. Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre: Reassessment in the Era of Ancillary Molecular Diagnosis

    Khin Thway, Jayson Wang, Taka Mubako et al. — Sarcoma · 2014 · cited 62 times

86. Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience

    Naofumi Asano, Michiro Susa, Seiichi Hosaka et al. — Sarcoma · 2012 · cited 61 times

87. Granular Cell Tumours: A Rare Entity in the Musculoskeletal System

    Barry Rose, George S. Tamvakopoulos, Eric Yeung et al. — Sarcoma · 2009 · cited 59 times

88. Confirmed Angiosarcoma: Prognostic Factors and Outcome in 50Prospectively Followed Patients

    N. Joseph Espat, J J Lewis, James M. Woodruff et al. — Sarcoma · 2000 · cited 59 times

89. Chondrosarcoma of the Pelvis: Oncologic and Functional Outcome

    Reiner Wirbel, M. Schulte, Bernd Maier et al. — Sarcoma · 2000 · cited 59 times

90. Phase II Trial of Gemcitabine and Docetaxel with Bevacizumab in Soft Tissue Sarcoma

    Mark Andrew Dickson, David R. D’Adamo, Mary Louise Keohan et al. — Sarcoma · 2015 · cited 58 times

91. Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years

    Andrew J. Jacobs, Ryan D. Michels, Joanna Stein et al. — Sarcoma · 2015 · cited 58 times

92. Analysis of the Intratumoral Adaptive Immune Response in Well Differentiated and Dedifferentiated Retroperitoneal Liposarcoma

    William W. Tseng, Shruti Malu, Minying Zhang et al. — Sarcoma · 2015 · cited 58 times

93. Prognostic and Survival Factors in Myxofibrosarcomas

    Varun Dewan, Anna Darbyshire, Vaiyapuri P. Sumathi et al. — Sarcoma · 2012 · cited 58 times

94. Primary Cardiac Angiosarcoma

    Dhatri Kodali, Kala Seetharaman — Sarcoma · 2006 · cited 58 times

95. The Treatment and Outcome of Patients With Soft Tissue Sarcomas and Synchronous Metastases

    John Michael Kane, J. William Finley, Deborah Driscoll et al. — Sarcoma · 2002 · cited 58 times

96. Treatment of Sarcoma Lung Metastases with Stereotactic Body Radiotherapy

    Adam D. Lindsay, Edward E. Haupt, Chung Ming Chan et al. — Sarcoma · 2018 · cited 57 times

97. Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations

    David Olmos, Ana Sofia Martins, Robin L. Jones et al. — Sarcoma · 2011 · cited 57 times

98. Surmounting Chemotherapy and Radioresistance in Chondrosarcoma: Molecular Mechanisms and Therapeutic Targets

    Anne C. Onishi, Alexander M. Hincker, Francis Y. Lee — Sarcoma · 2010 · cited 57 times

99. Primary Cardiac Sarcoma: A Rare, Aggressive Malignancy with a High Propensity for Brain Metastases

    Brittany L. Siontis, Lili Zhao, Monika Jacquelina Leja et al. — Sarcoma · 2019 · cited 56 times

100. Dkk-3, a Secreted Wnt Antagonist, Suppresses Tumorigenic Potential and Pulmonary Metastasis in Osteosarcoma

     Carol Hwang Lin, Yi Guo, Samia Ghaffar et al. — Sarcoma · 2013 · cited 56 times

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