Classic Papers in Orthopaedic Oncology

Pool built 2026-08-26 · All specialties

These are the 100 most-cited papers published in the Orthopaedic Oncology journals, ranked by lifetime citations (via OpenAlex; retracted papers excluded). The daily digest draws its classic slot from this pool — subscribe to get one with your new articles, or browse the Orthopaedic Oncology archive.

1. Guidelines for the Management of Soft Tissue Sarcomas

   R. J. Grimer, Ian Judson, D. Peake et al. — Sarcoma · 2010 · cited 431 times

2. The Molecular Pathogenesis of Osteosarcoma: A Review

   Matthew L. Broadhead, Jonathan C. M. Clark, Damian E. Myers et al. — Sarcoma · 2011 · cited 350 times

3. Using Epidemiology and Genomics to Understand Osteosarcoma Etiology

   Sharon A. Savage, Lisa Mirabello — Sarcoma · 2011 · cited 325 times

4. The Intergroup Rhabdomyosarcoma Study Group (IRSG): Major Lessons From the IRS‐I Through IRS‐IV Studies as Background for the Current IRS‐V Treatment Protocols

   R. Beverly Raney, Harold M. Maurer, James R. Anderson et al. — Sarcoma · 2001 · cited 315 times

5. Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS, and SIOG

   Peyman Hadji, Matti Aapro, Jean-Jacques Body et al. — J Bone Oncol · 2017 · cited 280 times

6. Benign tumours of the bone: A review

   David Hakim, T. Pelly, Myutan Kulendran et al. — J Bone Oncol · 2015 · cited 259 times

7. The Classic: A System for the Surgical Staging of Musculoskeletal Sarcoma

   William F. Enneking, Suzanne S. Spanier, Mark A. Goodman — Clin Orthop Relat Res · 2003 · cited 259 times

8. The Genetics of Osteosarcoma

   Jeff W. Martin, Jeremy A. Squire, Maria Zieleńska — Sarcoma · 2012 · cited 258 times

9. Metastatic bone disease: Pathogenesis and therapeutic options

   Stella D’Oronzo, Robert E. Coleman, Janet E. Brown et al. — J Bone Oncol · 2018 · cited 257 times

10. “Malignant” Perivascular Epithelioid Cell Neoplasm: Risk Stratification and Treatment Strategies

    Jonathan Bleeker, J. Fernando Quevedo, Andrew L. Folpe — Sarcoma · 2012 · cited 215 times

11. Liposarcoma: Molecular Genetics and Therapeutics

    Rachel Conyers, Sophie Young, David M. Thomas — Sarcoma · 2010 · cited 214 times

12. A Pilot Study of Anti-CTLA4 Antibody Ipilimumab in Patients with Synovial Sarcoma

    Robert G. Maki, Achim A. Jungbluth, Sacha Gnjatic et al. — Sarcoma · 2013 · cited 180 times

13. Survival in Malignant Peripheral Nerve Sheath Tumours: A Comparison between Sporadic and Neurofibromatosis Type 1-Associated Tumours

    D. Porter, Vishal Prasad, L. Bryant Foster et al. — Sarcoma · 2009 · cited 172 times

14. Advances in immune checkpoint inhibitors for bone sarcoma therapy

    Pichaya Thanindratarn, Dylan C. Dean, Scott D. Nelson et al. — J Bone Oncol · 2019 · cited 165 times

15. The role of tumour-associated macrophages in bone metastasis

    Sofia Sousa, Jorma A. Määttä — J Bone Oncol · 2016 · cited 164 times

16. Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers

    Aude I. Ségaliny, Marta Tellez Gabriel, Marie‐Françoise Heymann et al. — J Bone Oncol · 2015 · cited 159 times

17. MicroRNA Involvement in Osteosarcoma

    Eisuke Kobayashi, Francis J. Hornicek, Zhenfeng Duan — Sarcoma · 2012 · cited 154 times

18. The Role of RUNX2 in Osteosarcoma Oncogenesis

    Jeff W. Martin, Maria Zieleńska, Gary S. Stein et al. — Sarcoma · 2010 · cited 148 times

19. Risk and clinicopathological features of osteosarcoma metastasis to the lung: A population-based study

    Xiaoyi Huang, Jian Zhao, Jinyi Bai et al. — J Bone Oncol · 2019 · cited 145 times

20. Computer-Assisted Planning and Patient-Specific Instruments for Bone Tumor Resection within the Pelvis: A Series of 11 Patients

    F. Gouin, Paul Laurent, Guillaume Odri et al. — Sarcoma · 2014 · cited 144 times

21. The role of CXCR4 in multiple myeloma: Cells’ journey from bone marrow to beyond

    Tomalika R. Ullah — J Bone Oncol · 2019 · cited 143 times

22. Identification of Differentially Expressed MicroRNAs in Osteosarcoma

    Rishi Lulla, Fabrício F. Costa, Jared M. Bischof et al. — Sarcoma · 2011 · cited 143 times

23. Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family

    Heinrich Kovar — Sarcoma · 2010 · cited 138 times

24. Clinical Features of Sarcomatoid Carcinoma (Carcinosarcoma) of the Urinary Bladder: Analysis of 221 Cases

    Jue Wang, Fen Wang, Chad A. LaGrange et al. — Sarcoma · 2010 · cited 130 times

25. Quality of Life Implications as a Consequence of Surgery: Limb Salvage, Primary and Secondary Amputation

    Christine Eiser, Anne‐Sophie Darlington, Chris Stride et al. — Sarcoma · 2001 · cited 127 times

26. Malignant Peripheral Nerve Sheath Tumors State of the Science: Leveraging Clinical and Biological Insights into Effective Therapies

    AeRang Kim, Douglas R. Stewart, Karlyne M. Reilly et al. — Sarcoma · 2017 · cited 126 times

27. The role of osteoblasts in bone metastasis

    Penelope D. Ottewell — J Bone Oncol · 2016 · cited 122 times

28. Myeloma bone disease: Pathophysiology and management

    Rebecca Silbermann, G. David Roodman — J Bone Oncol · 2013 · cited 122 times

29. Incidence, consequences and treatment of bone metastases in breast cancer patients—Experience from a single cancer centre

    Iryna Kuchuk, Brian Hutton, Patrícia Moretto et al. — J Bone Oncol · 2013 · cited 118 times

30. Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma

    Patrick P. Lin, Yongxing Wang, Guillermina Lozano — Sarcoma · 2010 · cited 117 times

31. Prognostic Factors and Metastatic Patterns in Primary Myxoid/Round-Cell Liposarcoma

    J. Haniball, Vaiyapuri P. Sumathi, Lars‐Gunnar Kindblom et al. — Sarcoma · 2011 · cited 114 times

32. The Identification of Prognostic Factors and Survival Statistics of Conventional Central Chondrosarcoma

    Sjoerd Nota, Yvonne Braun, Joseph H. Schwab et al. — Sarcoma · 2015 · cited 113 times

33. Synovial Chondrosarcoma Arising in Synovial Chondromatosis

    Scott Evans, Michele Boffano, Samena Chaudhry et al. — Sarcoma · 2014 · cited 111 times

34. Desmoplastic Small Round Cell Tumor: Current Management and Recent Findings

    Armelle Dufresne, Philippe A. Cassier, L Couraud et al. — Sarcoma · 2012 · cited 111 times

35. Doxorubicin‐Based Chemotherapy for the Palliative Treatment of AdultPatients with Locally Advanced or Metastatic Soft‐Tissue Sarcoma:A Meta‐Analysis and Clinical Practice Guideline

    Vivien Bramwell, Dale Anderson, Manya Charette — Sarcoma · 2000 · cited 111 times

36. Bone metastases in thyroid cancer

    Nicole M. Iñiguez‐Ariza, Keith C. Bible, B.L. Clarke — J Bone Oncol · 2020 · cited 110 times

37. Incidence and consequences of bone metastases in lung cancer patients

    Michael Kuchuk, Christina Addison, Mark Clemons et al. — J Bone Oncol · 2013 · cited 110 times

38. Should Soft Tissue Sarcomas be Treated at a Specialist Centre?

    Aneel Bhangu, Jordan A. Beard, R. J. Grimer — Sarcoma · 2004 · cited 110 times

39. Overexpression of lncRNA UCA1 promotes osteosarcoma progression and correlates with poor prognosis

    Wu Li, Peng Xie, Wenhui Ruan — J Bone Oncol · 2016 · cited 109 times

40. Advances in limb salvage treatment of osteosarcoma

    Yichun Yang, Yichun Yang, Lei Han et al. — J Bone Oncol · 2017 · cited 108 times

41. The role of biomarkers in the management of bone-homing malignancies

    Stella D’Oronzo, Janet E. Brown, Robert E. Coleman — J Bone Oncol · 2017 · cited 108 times

42. FDG PET/CT in Initial Staging of Adult Soft-Tissue Sarcoma

    David Roberge, Siavosh Vakilian, Yazan Z. Alabed et al. — Sarcoma · 2012 · cited 107 times

43. MR imaging of clear cell sarcoma (malignant melanoma of the soft parts): a multicenter correlative MRI-pathology study of 21 cases and literature review

    L. H. De Beuckeleer, A. Schepper, J Vandevenne et al. — Skeletal Radiol · 2000 · cited 105 times

44. Separation surgery for metastatic epidural spinal cord compression: A qualitative review

    Giuseppe Di Perna, Fabio Cofano, Cristina Mantovani et al. — J Bone Oncol · 2020 · cited 104 times

45. Benefits and risks of adjuvant treatment with zoledronic acid in stage II/III breast cancer. 10 years follow-up of the AZURE randomized clinical trial (BIG 01/04)

    Robert E. Coleman, Michelle Collinson, Walter M. Gregory et al. — J Bone Oncol · 2018 · cited 103 times

46. Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

    Xin Sun, Wei Guo, Jacson Shen et al. — Sarcoma · 2015 · cited 102 times

47. SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors

    Christine S. Higham, Seth M. Steinberg, Eva Dombi et al. — Sarcoma · 2017 · cited 100 times

48. Stereotactic Body Radiotherapy for Metastatic and Recurrent Ewing Sarcoma and Osteosarcoma

    Lindsay C. Brown, Rachael Lester, Michael P. Grams et al. — Sarcoma · 2014 · cited 100 times

49. Intensified Adjuvant IFADIC Chemotherapy for Adult Soft Tissue Sarcoma: A Prospective Randomized Feasibility Trial

    T. Brodowicz, Eva Schwameis, Joachim Widder et al. — Sarcoma · 2000 · cited 100 times

50. Imaging Features of Superficial and Deep Fibromatoses in the Adult Population

    Eric A. Walker, Jonelle M. Petscavage, Pamela Brian et al. — Sarcoma · 2012 · cited 99 times

51. Solitary Fibrous Tumors and So-Called Hemangiopericytoma

    Nicolas Penel, Éric Amela, Gauthier Decanter et al. — Sarcoma · 2012 · cited 99 times

52. Clinicopathologic features and treatment of postirradiation sarcoma of bone and soft tissue

    Yoshiya Inoue, Frank J. Frassica, Franklin H. Sim et al. — J Surg Oncol · 2000 · cited 99 times

53. Frequency of Certain Established Risk Factors in Soft Tissue Sarcomas in Adults: A Prospective Descriptive Study of 658 Cases

    Nicolas Penel, Jessica Grosjean, Y Robin et al. — Sarcoma · 2008 · cited 95 times

54. Defective Osteogenic Differentiation in the Development of Osteosarcoma

    Eric R. Wagner, Gaurav Luther, Gaohui Zhu et al. — Sarcoma · 2011 · cited 94 times

55. Osteosarcoma: Evolution of Treatment Paradigms

    Norman Jaffe, Ajay Puri, Hans Gelderblom — Sarcoma · 2013 · cited 93 times

56. Chondrosarcoma: With Updates on Molecular Genetics

    Mi-Jung Kim, Kyung‐Ja Cho, Alberto G. Ayala et al. — Sarcoma · 2011 · cited 93 times

57. The anti-tumour effects of zoledronic acid

    Jamal Zekri, Maged Mansour, S.M.M. Karim — J Bone Oncol · 2014 · cited 92 times

58. Low-Grade Fibromyxoid Sarcoma: Incidence, Treatment Strategy of Metastases, and Clinical Significance of theFUSGene

    Katja Maretty-Nielsen, Steen Bærentzen, Johnny Keller et al. — Sarcoma · 2013 · cited 91 times

59. Updated guidance on the management of cancer treatment-induced bone loss (CTIBL) in pre- and postmenopausal women with early-stage breast cancer

    Komal Waqas, Joana Lima Ferreira, Elena Tsourdi et al. — J Bone Oncol · 2021 · cited 90 times

60. UK Guidelines for the Management of Bone Sarcomas

    R. J. Grimer, Nick Athanasou, Craig Gerrand et al. — Sarcoma · 2010 · cited 90 times

61. At-Risk Populations for Osteosarcoma: The Syndromes and Beyond

    George T. Calvert, R. Lor Randall, Kevin B. Jones et al. — Sarcoma · 2012 · cited 89 times

62. Ewing′s Sarcoma of the Head and Neck: A Retrospective Analysis of 24 Cases

    Ayman Allam, Gamal El-Husseiny, Yasser Khafaga et al. — Sarcoma · 1999 · cited 89 times

63. Fluorescence In Situ Hybridization for MDM2 Amplification as a Routine Ancillary Diagnostic Tool for Suspected Well-Differentiated and Dedifferentiated Liposarcomas: Experience at a Tertiary Center

    Khin Thway, Jayson Wang, John Swansbury et al. — Sarcoma · 2015 · cited 87 times

64. The role of osteoclasts in breast cancer bone metastasis

    François Le Pape, Geoffrey Vargas, Philippe Clézardin — J Bone Oncol · 2016 · cited 86 times

65. MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions

    Chandhanarat Chandhanayingyong, Yuhree Kim, J. Robert Staples et al. — Sarcoma · 2012 · cited 85 times

66. Characteristics and Patterns of Metastatic Disease from Chordoma

    Victoria A. Young, Kevin M. Curtis, H. Thomas Temple et al. — Sarcoma · 2015 · cited 84 times

67. Overexpression of ZEB1 relates to metastasis and invasion in osteosarcoma

    Aidong Shen, Yunqing Zhang, Huiguang Yang et al. — J Surg Oncol · 2011 · cited 83 times

68. Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes

    Faris Shweikeh, Laura Bukavina, Kashif Saeed et al. — Sarcoma · 2014 · cited 82 times

69. The role of 18F–NaF PET/CT in metastatic bone disease

    Mine Araz, Gülseren Araş, Özlem N. Küçük — J Bone Oncol · 2015 · cited 81 times

70. Alveolar Soft Part Sarcoma: A Single-Center 26-Patient Case Series and Review of the Literature

    Koichi Ogura, Yasuo Beppu, Hirokazu Chuman et al. — Sarcoma · 2012 · cited 81 times

71. Pathobiologic Markers of the Ewing Sarcoma Family of Tumors: State of the Art and Prediction of Behaviour

    Alfredo Pinto, Paul S. Dickman, David M. Parham — Sarcoma · 2010 · cited 81 times

72. Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistance

    Helin Feng, Jin Wang, Wei Chen et al. — J Bone Oncol · 2016 · cited 80 times

73. A Cadaveric Comparative Study on the Surgical Accuracy of Freehand, Computer Navigation, and Patient-Specific Instruments in Joint-Preserving Bone Tumor Resections

    Sarah E. Bosma, Kwok Chuen Wong, Laurent Paul et al. — Sarcoma · 2018 · cited 80 times

74. Blockade of CCL2 enhances immunotherapeutic effect of anti-PD1 in lung cancer

    Yue Wang, Xiaokai Zhang, Liangliang Yang et al. — J Bone Oncol · 2018 · cited 79 times

75. A comparative study between limb-salvage and amputation for treating osteosarcoma

    Xiaojuan Li, Ya Zhang, Shanshan Wan et al. — J Bone Oncol · 2016 · cited 79 times

76. The role of the bone microenvironment in skeletal metastasis

    Yu Zheng, Hong Zhou, Colin R. Dunstan et al. — J Bone Oncol · 2012 · cited 79 times

77. Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre

    Khin Thway, Cyril Fisher — Sarcoma · 2009 · cited 79 times

78. miRNA-223 is a potential diagnostic and prognostic marker for osteosarcoma

    Junbo Dong, Yilin Liu, Wensheng Liao et al. — J Bone Oncol · 2016 · cited 78 times

79. Spinal Chondrosarcoma: A Review

    Pavlos Katonis, Kalliopi Alpantaki, Konstantinos Michail et al. — Sarcoma · 2011 · cited 78 times

80. Surgical Guides (Patient-Specific Instruments) for Pediatric Tibial Bone Sarcoma Resection and Allograft Reconstruction

    Laura Bellanova, Laurent Paul, Pierre‐Louis Docquier — Sarcoma · 2013 · cited 77 times

81. Extraskeletal Osteosarcoma: Analysis of Outcome of a Rare Neoplasm

    Martin D. McCarter, Jonathan J. Lewis, Cristina R. Antonescu et al. — Sarcoma · 2000 · cited 77 times

82. Guidance for the assessment and management of prostate cancer treatment-induced bone loss. A consensus position statement from an expert group

    Janet E. Brown, Catherine Handforth, Juliet Compston et al. — J Bone Oncol · 2020 · cited 75 times

83. Computer-Assisted Resection and Reconstruction of Pelvic Tumor Sarcoma

    Pierre‐Louis Docquier, Laurent Paul, Olivier Cartiaux et al. — Sarcoma · 2010 · cited 75 times

84. Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016)

    Brigitte C. Widemann, Yao Lu, Denise K. Reinke et al. — Sarcoma · 2019 · cited 74 times

85. Aneurysmal bone cyst: A review of 65 patients

    Ferdinand Grahneis, Alexander Klein, Andrea Baur‐Melnyk et al. — J Bone Oncol · 2019 · cited 73 times

86. The Influence of Elementary Silver Versus Titanium on Osteoblasts Behaviour In Vitro Using Human Osteosarcoma Cell Lines

    Jendrik Hardes, Arne Streitbürger, H. Ahrens et al. — Sarcoma · 2007 · cited 73 times

87. Thallium-201 scanning for the evaluation of osteosarcoma and soft-tissue sarcoma. A study of the evaluation and predictability of the histological response to chemotherapy.

    Lawrence R. Menendez, B M Fideler, JosephM. Mirra — J Bone Joint Surg Am · 1993 · cited 73 times

88. The bone metastasis niche in breast cancer: potential overlap with the haematopoietic stem cell niche in vivo

    Gloria Allocca, Russell Hughes, Ning Wang et al. — J Bone Oncol · 2019 · cited 71 times

89. Can Experienced Observers Differentiate between Lipoma and Well-Differentiated Liposarcoma Using Only MRI?

    Patrick W. O’Donnell, Anthony M. Griffin, William C. Eward et al. — Sarcoma · 2013 · cited 71 times

90. Current strategies for the treatment of solitary and aneurysmal bone cysts: A review of the literature

    Niklas Deventer, Niklas Deventer, Nils Deventer et al. — J Bone Oncol · 2021 · cited 70 times

91. New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma

    Xingyu Chang, Zhanjun Ma, Guomao Zhu et al. — J Bone Oncol · 2021 · cited 70 times

92. Role of autophagy in osteosarcoma

    Olivier Camuzard, Sabine Santucci‐Darmanin, Georges F. Carle et al. — J Bone Oncol · 2019 · cited 70 times

93. The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets

    Emmanuelle David, Frédéric Blanchard, Marie‐Françoise Heymann et al. — Sarcoma · 2011 · cited 70 times

94. Delays in Referral of Soft Tissue Sarcomas

    Graham Johnson, G. Smith, Asterios Dramis et al. — Sarcoma · 2008 · cited 69 times

95. Quality of life after palliative radiotherapy in bone metastases: A literature review

    Rachel McDonald, Edward Chow, Leigha Rowbottom et al. — J Bone Oncol · 2014 · cited 68 times

96. Desmoplastic Small Round Blue Cell Tumor: A Review of Treatment and Potential Therapeutic Genomic Alterations

    Ajaz Bulbul, Bridget N. Fahy, Joanne Xiu et al. — Sarcoma · 2017 · cited 68 times

97. Giant Cell Tumors of the Axial Skeleton

    Maurice Balke, M. Henrichs, Georg Gosheger et al. — Sarcoma · 2012 · cited 68 times

98. Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023)

    AeRang Kim, Yao Lu, Scott H. Okuno et al. — Sarcoma · 2020 · cited 67 times

99. Intercalary Reconstructions with Vascularised Fibula and Allograft after Tumour Resection in the Lower Limb

    Katharina Rabitsch, Werner Maurer-Ertl, U. Pirker-Frühauf et al. — Sarcoma · 2013 · cited 67 times

100. Soft Tissue Tumours of the Retroperitoneum

     J. Frans Graadt van Roggen, Pancras C.W. Hogendoorn — Sarcoma · 2000 · cited 67 times

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