Latest research on opioid prescribing

20 papers · updated 2026-09-26 · General Orthopaedics · All topics

The newest papers on opioid prescribing from the orthopaedic journals The Reduction reads, newest first, each with a one-line summary. The list is drawn from the digest’s archive and refreshed every week.

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Recent papers

  1. Patients Undergoing Revision Total Knee Arthroplasty for Stiffness Have Similar Perioperative Pain Scores and Postoperative Opioid Consumption Compared to Patients Undergoing Revisions for Other Aseptic Indications.

    Journal of Arthroplasty · Sep 16 2026 · PubMed

    Despite worse clinical outcomes, patients undergoing revision TKA for stiffness had similar postoperative pain scores and opioid consumption compared to those revised for other aseptic reasons.

  2. Preoperative Selective Serotonin Reuptake Inhibitor (SSRI) Use Is Associated With Pseudoarthrosis and Increased Opioid Utilization Across Anterior and Posterior Cervical Spine Fusion: A Propensity-Matched Cohort Analysis.

    Clinical Spine Surgery · Aug 17 2026 · PubMed

    Preoperative SSRI use was linked to higher rates of pseudoarthrosis and substantially greater postoperative opioid use after both anterior and posterior cervical fusion in this propensity-matched analysis.

  3. Administration of Preoperative Cryoneurolysis is Associated with Continued and Persistent Opioid Reduction and Improved Outcomes in Primary Total Knee Arthroplasty.

    Journal of Arthroplasty · Aug 14 2026 · PubMed

    In a multicenter registry of 351 primary TKA patients, preoperative cryoneurolysis reduced postoperative opioid use and pain severity through six months and modestly improved KOOS JR function scores, supporting its use as an opioid-sparing adjunct.

  4. The Impact of Opioid-Related Disorder on Healthcare Resource Utilization Following Distal Radius Fracture Repair Surgery.

    Journal of Hand Surgery (Global Online) · Aug 11 2026 · PubMed

    Patients with opioid-related disorder had significantly higher ED visits, hospitalizations, PT evaluations, and opioid prescriptions after distal radius fracture repair than matched non-ORD patients.

  5. Regional Anesthesia in Thumb Carpometacarpal Arthroplasty: Increased Costs Without Differences in Early Emergency Department Visits or Opioid Prescriptions.

    Journal of Hand Surgery (Global Online) · Aug 07 2026 · PubMed

    In over 33,000 matched patients, regional nerve blocks for thumb CMC arthroplasty raised costs without reducing early ED visits or opioid prescriptions, questioning their routine use.

  6. A Quality Initiative for Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis (AIS): Liposomal Bupivacaine With Dexamethasone Use Results in Substantial Reduction in Inpatient Opioid Use.

    Journal of Pediatric Orthopaedics · Jul 13 2026 · PubMed

    In AIS spinal fusion patients, replacing PCA-based opioid regimens with liposomal bupivacaine plus dexamethasone markedly cut opioid use and shortened hospital stay without worsening pain control.

  7. From surgical backlog to opioid burden : the case for opioid stewardship in arthroplasty pathways.

    The Bone & Joint Journal · Jul 01 2026 · Review · PubMed

    Annotation argues for opioid stewardship throughout arthroplasty care pathways to counter rising perioperative opioid reliance amid prolonged surgical wait times.

  8. Implementing Evidence-based Opioid Prescribing in Pediatric Orthopaedics.

    Journal of the American Academy of Orthopaedic Surgeons · Jul 01 2026 · Review · PubMed

    Reviews POSNA opioid prescribing guidelines for pediatric orthopaedic surgery, highlighting implementation barriers and strategies to safely optimize postoperative pain control.

  9. Antipsychotic Medications are Associated with Higher Rates of Healthcare Utilization, Complications, Opioid Prescriptions, and Subsequent Cervical Surgery after Anterior Cervical Discectomy and Fusion.

    Spine · Jun 22 2026 · PubMed

    Antipsychotic medications increase ACDF complications, healthcare utilization, opioid prescriptions, and subsequent cervical surgery.

  10. Fragmented Sleep And Opioid Medication Utilization During Hospitalization Following Orthopaedic Trauma.

    Journal of Orthopaedic Trauma · Jun 22 2026 · PubMed

    Orthopaedic trauma inpatients experience short, fragmented sleep, and higher opioid use is independently associated with worse sleep quality during hospitalization.

  11. The Impact of Preoperative Cannabis Use on Postoperative Pain and Opioid Use in Orthopaedic Surgery Patients: A Scoping Review.

    Journal of the American Academy of Orthopaedic Surgeons · Jun 15 2026 · Review · PubMed

    Evidence suggests preoperative cannabis use does not significantly affect postoperative opioid consumption after orthopaedic surgery, though pain outcomes remain mixed.

  12. Perioperative Pain Management in Patients Being Treated for Opioid Use Disorder: The Orthopaedic Surgeon's Role and Strategies for Comprehensive Care.

    Journal of the American Academy of Orthopaedic Surgeons · May 15 2025 · Review · PubMed

    Orthopaedic surgeons must understand OUD medications and multimodal pain strategies to safely manage postoperative pain without precipitating relapse or undertreating acute pain.

  13. Opioids and Youth Athletes.

    Sports Health · Feb 16 2024 · Review · PubMed

    This narrative review finds opioid use is common among youth athletes (28-46% lifetime use in high schoolers), with sports participation itself linked to greater risk of future opioid misuse.

  14. Evidenced-Based Opioid Prescribing Recommendations Following Hand and Upper-Extremity Surgery.

    Journal of Hand Surgery (Global Online) · Sep 2022 · Review · PubMed

    This review provides evidence-based opioid prescribing recommendations for common hand and upper-extremity procedures to combat overprescribing and reduce opioid misuse.

  15. Opioid Stewardship in Orthopaedic Surgery: Principles and Practice.

    JBJS Reviews · Aug 2020 · Review · PubMed

    This review outlines opioid stewardship principles—multidisciplinary, evidence-based prescribing practices—to help orthopaedic surgeons combat opioid overuse and misuse.

  16. A Review of Inpatient Opioid Consumption and Discharge Prescription Patterns After Orthopaedic Procedures.

    Journal of the American Academy of Orthopaedic Surgeons · Apr 01 2020 · Review · PubMed

    Discharge opioid prescriptions exceed inpatient consumption; prescribing amounts that approximate inpatient use reduces overprescription without increasing refill rates.

  17. Confronting the Opioid Crisis: Practical Pain Management and Strategies: AOA 2018 Critical Issues Symposium.

    Journal of Bone and Joint Surgery (American) · Dec 04 2019 · Review · PubMed

    This AOA symposium report addresses the opioid crisis in orthopaedics, urging multimodal, non-narcotic pain management strategies and policy changes to reduce perioperative opioid overprescribing.

  18. Ethics of Opioid Prescriber Regulations: Physicians, Patients, and Pain.

    Journal of Bone and Joint Surgery (American) · Dec 04 2019 · Review · PubMed

    Ethical review finds most opioid-prescribing interventions sound, but rigid prescribing limits without patient/procedure accommodation may harm appropriate pain care.

  19. Opioid-Sparing Pain Management in Upper Extremity Surgery: Part 1: Role of the Surgeon and Anesthesiologist.

    Journal of Hand Surgery (American) · Sep 2019 · Review · PubMed

    Multimodal anesthesia combining regional blocks and non-opioid adjuncts significantly reduces opioid requirements during upper extremity surgery, with guidance for surgeons and anesthesiologists.

  20. What Orthopaedic Surgeons Need to Know: The Basic Science Behind Opioids.

    Journal of the American Academy of Orthopaedic Surgeons · Sep 15 2019 · Review · PubMed

    This review outlines the pharmacologic basics of opioid and nonopioid analgesics to help orthopaedic surgeons prescribe more responsibly amid the opioid epidemic.

Landmark papers

  1. Opioid Consumption Following Outpatient Upper Extremity Surgery

    Journal of Hand Surgery (American) · 2012 · cited 398 times · PubMed

    Study found patients after outpatient upper extremity surgery used far fewer opioid pills than prescribed, supporting smaller initial prescriptions to reduce diversion risk.

  2. Risk of Prolonged Opioid Use Among Opioid-Naïve Patients Following Common Hand Surgery Procedures

    Journal of Hand Surgery (American) · 2016 · cited 359 times · PubMed

    About 13% of opioid-naïve patients continued filling opioid prescriptions 90–180 days after common hand surgeries, underscoring need for preoperative risk-based opioid-sparing strategies.

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