Latest research on venous thromboembolism prophylaxis

12 papers · updated 2026-09-26 · General Orthopaedics · All topics

The newest papers on venous thromboembolism prophylaxis from the orthopaedic journals The Reduction reads, newest first, each with a one-line summary. The list is drawn from the digest’s archive and refreshed every week.

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Recent papers

  1. Risk of venous thromboembolism after knee, hip, or shoulder arthroplasty : a retrospective cohort study of 476,620 procedures using linked hospital and primary care data.

    The Bone & Joint Journal · Sep 01 2026 · PubMed

    In a UK cohort of 476,620 arthroplasties, VTE rates fell over time for hip and knee (but not clearly due to NICE guidelines), while a 2018 guideline update was linked to a 9% VTE reduction after shoulder arthroplasty.

  2. The Impact of Anticoagulant Choice on Rates of Manipulation Under Anesthesia, Hematoma Formation, and Venous Thromboembolic Events.

    Journal of Arthroplasty · Jul 2026 · PubMed

    Aspirin for thromboprophylaxis after total knee arthroplasty reduced manipulation under anesthesia rates by 26-38% and hematoma formation by 26-69% compared to potent anticoagulants without increasing clotting risk.

  3. Low-Dose Aspirin Once Daily Is Noninferior for Venous Thromboembolic Prophylaxis After Primary Total Joint Arthroplasty: An Analysis of 8,073 Cases Over 10 Years.

    Journal of Arthroplasty · Jul 15 2026 · PubMed

    Among 8,073 primary hip/knee arthroplasty patients, once-daily 81 mg aspirin achieved a low VTE rate (1.1%) statistically noninferior to twice-daily aspirin or stronger anticoagulants, supporting simplified dosing.

  4. Incidence of Lower Extremity Deep Vein Thrombosis Following Arthroscopic Rotator Cuff Repair.

    Journal of Shoulder and Elbow Surgery · Jun 24 2026 · PubMed

    Asymptomatic DVT occurs in 5.3% after rotator cuff repair; routine screening not recommended given distal location and asymptomatic presentation.

  5. Transfusions are Associated with an Elevated Risk of Venous Thromboembolism and Periprosthetic Joint Infection following Revision Total Knee Arthroplasty.

    Journal of Arthroplasty · Jun 17 2026 · PubMed

    Blood transfusions after revision TKA increase pulmonary embolism, DVT, and periprosthetic infection risks within 90 days.

  6. Extended Postoperative Risk of Venous Thromboembolism After Degenerative Spine Surgery: A Nationwide Cohort Study.

    Spine · Jun 12 2026 · PubMed

    VTE risk after degenerative spine surgery stays elevated up to four months, peaking at month two, supporting extended thromboembolic surveillance beyond the early perioperative window.

  7. Aspirin is Associated with Improved Venous Thromboembolism Prophylaxis Compared with Anticoagulants After Total Hip Arthroplasty in Patients Who Have Prior Hematologic Malignancy.

    Journal of Arthroplasty · Jun 09 2026 · PubMed

    Aspirin prophylaxis after THA in patients with prior hematologic malignancy reduces VTE risk and complications compared to anticoagulants, supporting its use as safe option.

  8. The effect of early tourniquet release on primary total knee arthroplasty and an analysis of risk factors for deep vein thrombosis.

    The Knee · Jun 04 2026 · PubMed

    Early tourniquet release in primary total knee arthroplasty reduced proximal DVT incidence without affecting clinical outcomes or blood loss.

  9. Venous thromboembolism in children with lower limb fractures: A systematic review and meta-analysis.

    Injury · Jun 03 2026 · PubMed

    Venous thromboembolism occurs infrequently in children with lower limb fractures at 0.53% rate; evidence for pharmacological prophylaxis remains sparse.

  10. Infection following foot and ankle surgery : a subanalysis of data captured from the UK Foot and Ankle Thromboembolism (FATE) audit.

    The Bone & Joint Journal · Jun 01 2026 · PubMed

    Superficial and deep infection rates after foot-ankle surgery were 4.1% and 1.4%; diabetic and trauma procedures had significantly higher infection rates.

  11. Update on Venous Thromboembolism in Orthopaedic Trauma Surgery.

    Journal of the American Academy of Orthopaedic Surgeons · Oct 01 2024 · Review · PubMed

    Recent evidence shows aspirin noninferior to anticoagulants for VTE prevention in orthopaedic trauma; direct oral anticoagulants offer promising alternatives.

  12. Venous Thromboembolic Prophylaxis After Total Hip and Knee Arthroplasty.

    Journal of Bone and Joint Surgery (American) · Aug 18 2021 · Review · PubMed

    No single VTE prophylaxis agent is proven superior after hip/knee arthroplasty—aspirin is increasingly popular, but risk-stratified, shared decision-making remains key to balancing clot versus bleeding risk.

Landmark papers

  1. Oral Thrombin Inhibitor Dabigatran Etexilate vs North American Enoxaparin Regimen for Prevention of Venous Thromboembolism After Knee Arthroplasty Surgery

    Journal of Arthroplasty · 2008 · cited 631 times · PubMed

    Dabigatran showed inferior efficacy compared to twice-daily enoxaparin 30 mg for venous thromboembolism prevention after total knee arthroplasty.

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