32 papers, newest 30 shown · updated 2026-09-26 · Orthopaedic Oncology · All topics
The newest papers on bone metastases from the orthopaedic journals The Reduction reads, newest first, each with a one-line summary. The list is drawn from the digest’s archive and refreshed every week.
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In 59 patients undergoing separation surgery for metastatic spinal cord compression, MRI-confirmed successful decompression at 2-3 weeks was linked to better motor recovery, ambulation, shorter hospital stay, and longer survival.
Tumour-to-tumour metastasis: head and neck squamous cell carcinoma to enchondroma.
Tumor-to-tumor metastasis of head and neck squamous cell carcinoma to benign enchondroma is exceptionally rare, representing an unusual malignancy pattern.
CT features of sclerotic margin distribution and thickness reliably differentiate Schmorl's nodes from osteolytic metastases without radiomics enhancement.
In 796 spinal metastasis surgery patients, allogenic RBC transfusion was independently and dose-dependently associated with higher 30-day infection risk with no safe transfusion threshold identified, supporting restrictive transfusion strategies.
Postoperative vascular endothelial growth factor inhibitor reintiation after 40 days reduced wound complications in spinal metastasis surgery compared with earlier resumption.
Intramedullary Reaming Biopsy in Diagnosing Metastatic Long Bone Disease.
Intramedullary reaming biopsy has 70% sensitivity for diagnosing metastatic disease in long bone lesions; formal open biopsy should be considered for negative results.
What Is the 5-year Survival of Patients With or Without Surgery in Spinal Metastatic Disease?
In a large registry, only about 9% of spinal metastasis patients survived 5 years, with SORG and NESMS scores remaining strong predictors of long-term survival to guide surgical decision-making.
Clinical application of urinary NTx in patients with bone metastases from lung cancer.
Urinary NTx/creatinine ratio effectively identifies bone metastases in lung cancer patients, and combining it with serum ALP and calcium substantially improves diagnostic accuracy (AUC 0.882 vs 0.78 alone).
Single-cell transcriptomics identifies ADAMTS12 and RNASE1 as key drivers of osteosarcoma metastatic progression through malignant and immune cell signaling networks.
Carbon fiber-reinforced PEEK and titanium spinal implants show comparable survival and local disease control in vertebral metastases treatment.
A 10-year Thai national cohort of over 16,000 spinal metastasis surgeries found rising surgical volume and comorbidity burden, with a 12.8% complication rate and 4.2% in-hospital mortality.
In this Danish cohort of 281 patients with proximal femur metastases, endoprosthetic reconstruction had lower implant failure and better overall survival than osteosynthesis, though revision rates were similar.
In advanced NSCLC patients on chemo-immunotherapy, higher bone metastatic burden on imaging was the strongest independent predictor of worse overall survival compared to other metastatic sites.
In newly diagnosed prostate cancer, serum preptin levels did not differ between patients with and without bone metastasis, indicating it is not a useful biomarker for metastatic status.
In 22 patients, en-bloc thoracolumbar spondylectomy for spinal tumors achieved good oncologic control (5-year overall survival 64%) but high morbidity, with marginal margins seeming adequate while intralesional margins were linked to recurrence.
Spinal metastases from lung cancer carry higher one-year mortality; surgical intervention and good nutritional status improve survival, while immunotherapy shows only short-term benefit.
Lower denosumab doses reduced skeletal-related events risk while decreasing osteonecrosis of the jaw risk in metastatic cancer patients, suggesting dose reduction may optimize the benefit-harm profile.
Novel separation surgery with vertebroplasty and iodine-125 seed implantation provides minimally invasive decompression and local control for thoracic metastatic spinal cord compression.
A novel nomogram integrating inflammatory-nutritional markers outperforms traditional anatomical scoring systems for predicting survival in spinal metastases treated with minimally invasive surgery.
Recombinant LGR4 extracellular domain inhibits osteoclast formation and reduces bone metastasis burden by 67%, suggesting novel therapeutic potential.
Preoperative hypoalbuminemia independently predicts 30-day complications, mortality, and non-home discharge in dose-dependent fashion after spinal metastasis surgery.
Meta-analysis suggests cement-augmented pedicle screws may lower hardware failure rates versus conventional fixation in metastatic spine surgery (4.3% vs 12.5%), but evidence certainty is low.
Impact of complications on survival after surgery for metastatic spinal cord compression.
Postoperative systemic complications independently reduce survival after metastatic spinal cord compression surgery; impaired preoperative ambulation predicts higher complication risk and should guide surgical decision-making.
Random Forest and sparse elastic-net models effectively predict one-month postoperative performance status after spinal metastasis surgery with good discrimination.
The East Asian EAST-BMS machine-learning tool predicts postoperative survival in nonspinal bone metastasis surgery with better calibration than the Western SORG model for this population.
This review details C-arm–guided percutaneous techniques for minimally invasive stabilization and local control of periacetabular osteolytic metastases, avoiding morbidity of open reconstruction.
The Landmark Series: Multimodal Management of Oligometastatic Sarcoma.
This review discusses multidisciplinary use of metastasis-directed local therapies (SABR, ablation, metastasectomy) for oligometastatic sarcoma, weighing pros/cons of each modality in complex oncologic care.
Radiation Therapy for Primary and Metastatic Spine Tumors.
This review covers modern radiation therapy principles, techniques, and multidisciplinary management strategies for primary and metastatic spine tumors.
This AAOS-endorsed guideline offers seven evidence-based recommendations for surgical management of metastatic, myeloma, and lymphoma disease of the humerus.
Cemented total hip arthroplasty and porous tantalum reconstructions provide stable, durable constructs for acetabular metastases, enabling immediate weight-bearing and functional independence.
A Revised Scoring System for Preoperative Evaluation of Metastatic Spine Tumor Prognosis
Revised Tokuhashi scoring system predicted metastatic spinal tumor survival with 82-86% accuracy, guiding treatment selection between excisional and palliative surgical approaches.
This classic paper introduces Mirels' scoring system, combining site, pain, lesion type, and size to predict pathologic fracture risk in metastatic long bone lesions and guide prophylactic fixation decisions.
Metastatic bone disease: Pathogenesis and therapeutic options
This review summarizes the pathogenesis of bone metastases and current/novel bone-targeting therapies, noting mixed results of adjuvant bisphosphonates and denosumab across cancer types.
The role of tumour-associated macrophages in bone metastasis
This review explains how immunosuppressive M2-type tumour-associated macrophages promote bone metastasis across the metastatic cascade in breast, prostate cancer, and osteosarcoma, highlighting them as a potential therapeutic target.
In osteosarcoma, older age (>30) and larger tumors raised lung metastasis risk; surgery and chemotherapy improved survival while radiotherapy did not.
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