34 papers, newest 30 shown · updated 2026-09-26 · Orthopaedic Oncology · All topics
The newest papers on bone and soft tissue sarcoma from the orthopaedic journals The Reduction reads, newest first, each with a one-line summary. The list is drawn from the digest’s archive and refreshed every week.
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This review outlines how radiography, CT, MRI, and PET/CT each contribute to Ewing sarcoma diagnosis, staging, and treatment response assessment, with radiomics/AI emerging as promising tools for risk stratification.
In 51 sarcoma resections, ICG fluorescence with an SBR cutoff of 1.67 was highly sensitive for detecting positive margins but not specific enough to replace surgeon judgment, suggesting a combined approach could reduce local recurrence.
Multicomponent machine learning approach using multiple registries improves osteosarcoma survival prediction accuracy across diverse populations versus single data-set models.
In pediatric osteosarcoma patients, the Area Deprivation Index—unlike other social determinants of health measures—identified significant disparities in presentation delay, local recurrence, and overall survival.
Ewing's Sarcoma in Adults: A Predictive Nomogram and Survival Analysis of a Cohort of 937 Patients.
In 937 adults with Ewing sarcoma, a new nomogram incorporating age, stage, site, size, surgery, and chemotherapy predicted disease-specific survival better than stage alone, aiding individualized prognosis.
In cell and mouse models, pulsed electromagnetic fields killed osteosarcoma cells via ferroptosis while promoting normal bone healing, suggesting a noninvasive adjuvant therapy after tumor resection.
A machine-learning-derived centromere gene signature predicts osteosarcoma prognosis and immune microenvironment status, while B3GALT4 was validated as a tumor suppressor that inhibits osteosarcoma cell proliferation and migration.
Identification of immunopeptides (pHLA) as candidate therapeutic targets in chondrosarcoma.
Immunopeptidomic profiling of chondrosarcoma identified cancer/testis antigen-derived HLA-presented peptides—including known and novel targets—linked to poor prognosis, offering candidate targets for T-cell–based immunotherapies.
In chondrosarcoma spheroid models, Hippo/YAP-TAZ inhibition with Verteporfin increased radiosensitivity via autophagic disruption, apoptosis, and DNA damage, suggesting a potential strategy to overcome radioresistance.
Single-cell transcriptomics identifies ADAMTS12 and RNASE1 as key drivers of osteosarcoma metastatic progression through malignant and immune cell signaling networks.
LL-37 peptide inhibits osteosarcoma through PTEN/AKT/mTOR pathway targeting cholesterol synthesis, offering promising therapeutic potential.
For primary osseous chest wall sarcomas, R0 resection is the strongest survival predictor, with 5-year OS of 85% for chondrosarcoma, 67% Ewing, and only 38% for osteosarcoma.
Lapatinib induces ferroptosis in osteosarcoma via the SLC1A5-GPX4 axis.
Lapatinib induces ferroptosis in osteosarcoma via the SLC1A5-GPX4 axis in lab and mouse models, providing preclinical rationale for drug repurposing.
Delayed referral to a sarcoma center after unplanned soft-tissue sarcoma excision is independently associated with significantly higher metastasis rates and mortality, emphasizing urgent specialist referral.
Immunotherapy in the Treatment of Soft Tissue Sarcoma Since SARC028: An NCDB Analysis.
In this large NCDB analysis, anti-PD1 immunotherapy was associated with a ~20% mortality reduction in stage IV undifferentiated pleomorphic sarcoma but showed no benefit in stage III disease.
Reducing complications after resection of pelvic bone sarcomas : an aggregation of marginal gains.
Over 20 years, refinements in surgical approach, imaging, navigation, and centralization of care significantly reduced early return-to-theatre rates after pelvic sarcoma resection, though prosthetic reconstructions still have higher long-term revision rates.
Common quality-of-life measures underestimate physical functioning burden in sarcoma patients post-amputation; ICF framework highlights overlooked domains.
Consensus Guidelines on Perioperative Care in Primary Retroperitoneal Sarcoma Surgery.
First consensus perioperative guidelines for primary retroperitoneal sarcoma surgery provide multidisciplinary ERAS-based recommendations to standardize care and improve outcomes in this high-risk population.
In 23 sarcoma patients, post-treatment whole-tumor ADC values were highly reproducible and strongly predicted pathologic response to neoadjuvant radiotherapy, whereas sub-regional and longitudinal ADC changes were less reliable.
Pediatric and young adult osteosarcoma survivors have high natural fertility rates comparable to the general population, reassuring patients and families during treatment counseling.
Higher tumor-associated neutrophil density predicts poor neoadjuvant chemotherapy response in osteosarcoma; biopsy-based model enables early risk stratification.
Neoadjuvant EBRT with intraoperative IORT for retroperitoneal sarcoma carries 25% major complication rate, similar to EBRT alone with acceptable morbidity profile.
Age-related real-world treatment patterns and outcomes of localised, high-grade osteosarcoma.
Wide resection plus perioperative chemotherapy improves osteosarcoma survival at all ages; for patients over 40, guideline-concordant treatment remains the standard regardless of chemotherapy sequencing.
Neoadjuvant denosumab plus sunitinib for high-grade giant cell tumor of bone produced near-complete giant cell regression and 80% two-year disease-free survival, supporting further prospective study of this dual-targeted approach.
Unplanned soft tissue sarcoma excision independently worsened long-term survival and local recurrence, with differences emerging after 10 years, supporting extended surveillance.
Endoprosthetic Use in Pediatric and Adolescent Lower Limb Sarcoma Treatment.
This review discusses endoprosthetic reconstruction options, complications, and shared decision-making challenges in treating pediatric and adolescent lower limb sarcoma near the knee.
Ewing sarcoma tumor microenvironment includes immunosuppressive cells and molecules impairing anti-tumor immunity; targeting these offers therapeutic potential.
The Landmark Series: Multimodal Management of Oligometastatic Sarcoma.
This review discusses multidisciplinary use of metastasis-directed local therapies (SABR, ablation, metastasectomy) for oligometastatic sarcoma, weighing pros/cons of each modality in complex oncologic care.
Histology-Tailored Approach to Soft Tissue Sarcoma.
Surgery remains the curative cornerstone for soft tissue sarcoma, but management must be tailored to each histologic subtype and site to reduce local recurrence and metastasis.
This review finds PET-CT reliably tracks neoadjuvant treatment response and detects systemic recurrence in soft-tissue sarcomas but has limitations distinguishing benign from malignant uptake and detecting small pulmonary metastases.
A System for the Surgical Staging of Musculoskeletal Sarcoma
The Enneking surgical staging system provides a framework for classifying musculoskeletal sarcomas based on grade, site, and metastatic status to guide treatment.
Guidelines for the Management of Soft Tissue Sarcomas
UK consensus guidelines recommending multidisciplinary management, wide excision with postoperative radiotherapy, and selective chemotherapy for soft tissue sarcomas, emphasizing specialist team care.
A Meta-Analysis of Osteosarcoma Outcomes in the Modern Medical Era
Osteosarcoma survival plateaued since 1980 despite improved limb salvage rates; new systemic strategies needed to advance outcomes for this lethal malignancy.
The Molecular Pathogenesis of Osteosarcoma: A Review
This 2011 review outlines the molecular pathogenesis of osteosarcoma and emerging translational research aimed at identifying targeted therapies to improve outcomes beyond current anatomically based staging and treatment.
Using Epidemiology and Genomics to Understand Osteosarcoma Etiology
This review discusses osteosarcoma's poorly understood etiology, examining epidemiologic risk factors (Paget disease, radiation, height) and emerging genomic associations without identifying a strong environmental cause.
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