17 papers · updated 2026-09-26 · Sports Medicine · All topics
The newest papers on platelet-rich plasma and orthobiologics from the orthopaedic journals The Reduction reads, newest first, each with a one-line summary. The list is drawn from the digest’s archive and refreshed every week.
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LR-PRP showed modest benefit in reducing partial tendon tears and soft tissue edema in tennis elbow, but overall improvement was not superior to saline placebo.
An international Delphi panel reached broad consensus on best practices for orthobiologics (PRP, BMAC, exosomes, etc.) across various musculoskeletal indications, while highlighting persistent uncertainty in dosing, preparation, and standardization.
A Precision Medicine Framework to Improve Patient Care Using Orthobiologics.
Precision medicine frameworks can improve orthobiologic efficacy by accounting for patient and treatment heterogeneity to guide personalized therapy allocation.
Regulatory Frameworks and Clinical Development of Orthobiologics Across Asia and Europe.
Regulatory heterogeneity across Asia and Europe limits orthobiologics development; international collaboration is needed for safe, responsible innovation.
This meta-analysis shows intra-articular PRP outperforms placebo for knee OA pain/function at 6-12 months, but evidence certainty is very low and optimal PRP formulation remains unclear.
TRICARE's coverage of platelet-rich plasma injections without preauthorization increased utilization sixfold with questionable efficacy, highlighting risks of insurance coverage without evidence-based review.
Adding PRP or BMAC to ACL reconstruction grafts provided no clinical or MRI benefit over standard ACLR at 2 years, with BMAC potentially worsening graft signal intensity.
This ESSKA-ORBIT consensus recommends cell-based orthobiologic therapy as a second-line injectable for knee osteoarthritis (Kellgren-Lawrence 1-3, with some benefit in Grade 4) after other nonoperative treatments fail.
A 20-expert Delphi panel reached consensus on 85% of statements guiding ethical, transparent, and regulated use of orthobiologics, though cost and ethics issues remain unresolved.
An international expert panel issued 23 formal consensus recommendations on when PRP injections are appropriate or contraindicated in patients with infectious, oncologic, or hematologic comorbidities.
The role of orthobiologics in bone healing and joint and tendon degeneration in the upper limb.
PRP and MSCs show promise for bone healing but lack clinical evidence for tendinopathies and osteoarthritis; high-quality trials needed before widespread application in upper limb.
PRP or not PRP: Is the debate surrounding platelets-based blood-derived products evolving?
This review argues that inconsistent PRP preparation and classification (platelet count, leukocyte content, activation) hampers standardization, and calls for a unified classification system to guide clinical use of blood-derived orthobiologics.
Meta-analysis of 115 patients shows intra-articular PRP for thumb CMC osteoarthritis improves pain and pinch strength with high satisfaction and no major complications, though evidence heterogeneity warrants more RCTs before routine use.
Orthobiologic Augmentation to Improve Rotator Cuff Repair Outcomes: Current and Future Strategies.
Reviews biologic mechanisms of tendon-bone healing after rotator cuff repair and current augmentation strategies—bone marrow stimulation, PRP, and stem cell therapy—while previewing emerging cell-based treatments like extracellular vesicles.
This scoping review of 155 studies found most knee PRP research originates from Asia, focuses on injection for osteoarthritis, reports outcome improvements, but often lacks standardized PRP classification or MCID reporting.
Comparative Studies of Bone Graft and Orthobiologics for Foot Ankle Arthrodesis: A Critical Review.
Bone grafts and orthobiologic agents show variable efficacy for ankle/hindfoot arthrodesis; limited comparative evidence exists to guide material selection.
Reviews orthobiologic options like PRP and cell therapies for glenohumeral osteoarthritis in younger patients, noting promising but still inconclusive evidence.
This foundational review examines the basic science and clinical evidence for platelet-rich plasma in treating tendon, ligament, muscle, and bone injuries in sports medicine.
Treatment of Chronic Elbow Tendinosis with Buffered Platelet-Rich Plasma
In this small cohort study, a single platelet-rich plasma injection markedly reduced pain in chronic elbow tendinosis patients who had failed prior nonoperative treatment, suggesting it as an option before surgery.
Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis
In this RCT, PRP injections (single or double dose) significantly improved WOMAC scores in early knee osteoarthritis versus saline, though benefits waned somewhat by 6 months.
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