Latest research on cartilage repair

18 papers · updated 2026-09-26 · Sports Medicine · All topics

The newest papers on cartilage repair from the orthopaedic journals The Reduction reads, newest first, each with a one-line summary. The list is drawn from the digest’s archive and refreshed every week.

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Recent papers

  1. A Novel Mini-Prosthesis with a Nano-Multilayer Film-Coated Surface and 3D-Printed Porous Stem for Focal Cartilage Lesions: In Vivo Performance in a Porcine Model.

    Journal of Bone and Joint Surgery (American) · Sep 16 2026 · PubMed

    In a porcine model, a novel nano-coated 3D-printed mini-prosthesis for focal cartilage lesions showed superior cartilage protection and osseointegration compared with a standard CoCr implant or microfracture.

  2. Osteochondral Autograft Transfer for Focal Osteochondral Defects of the Knee: Indications, Technique, Outcomes, and Future Directions.

    Journal of Bone and Joint Surgery (American) · Sep 02 2026 · PubMed

    Osteochondral autograft transfer offers durable joint-preserving outcomes for focal articular cartilage defects in young patients with high return-to-sport rates exceeding 85%.

  3. Absorbable Suture Fixation of Osteochondral Fragments in Intra-articular Fractures of the Upper Extremity: A Surgical Technique.

    Journal of Hand Surgery (Global Online) · Sep 01 2026 · PubMed

    This technique paper describes using absorbable polydioxanone sutures to fix small osteochondral fragments in upper extremity intra-articular fractures, achieving union and joint congruity in a clinical case series.

  4. Poor mental health in patients with symptomatic osteochondral lesions of the talus.

    The Bone & Joint Journal · Sep 01 2026 · PubMed

    This prospective study found that most patients with symptomatic osteochondral talar lesions have mental health scores as poor as those with mood/anxiety disorders, persisting even after successful treatment, supporting integrated mental health care.

  5. A Novel Autologous Osteoperiosteal Composite for Osteochondral Regeneration.

    American Journal of Sports Medicine · Aug 2026 · PubMed

    Rabbit study shows an autologous osteoperiosteal composite graft outperforms microfracture in osteochondral defect repair, offering a promising single-stage cartilage regeneration strategy.

  6. Osteochondral Autograft Options for Reconstruction of Intra-articular Distal Humerus and Proximal Ulna Injuries in Physiologically Young Patients.

    Journal of Hand Surgery (Global Online) · Aug 08 2026 · PubMed

    CT-based surface mapping identified the hallux proximal phalanx, fibular head, and radial head as geometrically matched osteochondral autograft donor sites for reconstructing distal humerus and proximal ulna articular defects in young patients.

  7. Preoperative Proximal Migration of the Radial Head as an Independent Predictor of Suboptimal Outcomes After Osteochondral Autograft Transplantation for Capitellar Osteochondritis Dissecans: A Retrospective Cohort Study.

    American Journal of Sports Medicine · Aug 06 2026 · PubMed

    In adolescents undergoing osteochondral autograft transplantation for capitellar OCD, preoperative proximal migration of the radial head >2.2mm independently predicted suboptimal outcomes.

  8. Sex differences in osteochondral lesions of the talus: Lesion size reflects patients dimensions, whereas morphology differs between sexes.

    Foot and Ankle Surgery · Jul 26 2026 · PubMed

    In 250 patients with talar osteochondral lesions, apparent sex differences in lesion size were explained by patient height rather than sex itself, though females had higher odds of crater-type lesion morphology.

  9. Patient-specific talar resurfacing improves pain and function at 24 months in osteochondral lesions of the talus.

    Knee Surgery, Sports Traumatology, Arthroscopy · Jul 13 2026 · PubMed

    A prospective study of patient-specific talar resurfacing implants for osteochondral talar lesions showed sustained pain and functional improvement with high return-to-sport rates at 24 months.

  10. Bone Marrow Aspirate Concentrate Improves the Early Osseous Integration of Fresh Osteochondral Allografts in the Knee: A Randomized Controlled Trial.

    American Journal of Sports Medicine · Jun 2026 · PubMed

    BMAC augmentation improved early osseous integration of fresh osteochondral allografts at 3 months; no differences in clinical outcomes or later timepoints.

  11. Comparison of arthroscopic microfracture efficacy in osteochondral lesions of the talus with and without urate deposition.

    Foot and Ankle Surgery · Jun 18 2026 · PubMed

    Monosodium urate crystal deposition significantly impairs microfracture outcomes in osteochondral lesions; uric acid elevation is an independent adverse prognostic factor.

  12. ICRS-FIFA-Aspetar consensus on the management of knee cartilage injuries in football players: part 2-appropriateness of specific surgical procedures to address articular cartilage lesions in different clinical scenarios using the RAND/UCLA appropriateness method.

    British Journal of Sports Medicine · Jun 08 2026 · Review · PubMed

    An expert RAND/UCLA consensus finds surgical choice for knee cartilage lesions in footballers should be tailored to lesion characteristics and patient priority for quick return vs long-term results, favoring debridement+orthobiologics or regenerative techniques respectively while bone marrow stimulation is often inappropriate.

  13. Corrigendum to "Understanding Pain in Osteochondral Lesions of the Talus: A Cross-Sectional, CT‑Based Analysis Showing Limited and Inconsistent Associations With Pain".

    Foot & Ankle International · Jun 03 2026 · PubMed

    Corrigendum correcting a prior publication on CT-based pain associations in osteochondral lesions of the talus; read in conjunction with the original study for accurate interpretation.

  14. Comprehensive Landscape and Future Perspectives of Surgical Therapy for Osteochondral Lesions of the Talus: A Bibliometric Analysis From 1980 to 2024.

    Journal of the American Academy of Orthopaedic Surgeons · May 27 2026 · PubMed

    Bibliometric analysis shows surgical talus osteochondral lesion treatment evolves from traditional techniques toward biological augmentation and regenerative medicine.

  15. Personalized Resurfacing for Osteochondral Lesions of the Talus.

    Foot & Ankle Clinics · Jun 2024 · Review · PubMed

    Customized patient-specific metal inlays offer a joint-preserving bridge treatment for osteochondral talus lesions with more predictable results than prefabricated implants.

  16. A Comparison of Treatment of OCD Lesions of the Capitellum With Osteochondral Autograft and Allograft Transplantation.

    Journal of Hand Surgery (American) · Feb 2024 · Review · PubMed

    Review with case examples on choosing osteochondral autograft versus allograft for treating large, unstable capitellar OCD lesions in overhead athletes.

  17. Treatment of Osteochondral Fractures After Acute Patellofemoral Instability: A Critical Analysis Review.

    JBJS Reviews · Apr 08 2022 · Review · PubMed

    This review of osteochondral fractures after patellofemoral instability finds nonoperative treatment generally yields worse outcomes than surgery, but evidence comparing fixation versus loose body removal remains inconclusive, highlighting the need for high-quality RCTs.

  18. Next-Generation Marrow Stimulation Technology for Cartilage Repair: Basic Science to Clinical Application.

    JBJS Reviews · Jan 19 2021 · Review · PubMed

    Next-generation marrow stimulation scaffolds including hyaluronic acid and biosynthetic hydrogels show promise to overcome limitations of traditional microfracture and improve cartilage regeneration.

Landmark papers

  1. Clinical Efficacy of the Microfracture Technique for Articular Cartilage Repair in the Knee

    American Journal of Sports Medicine · 2009 · cited 1,017 times · PubMed

    This systematic review found microfracture gives good short-term knee function improvement but lacks strong long-term data, with variable cartilage fill and possible late deterioration.

  2. Autologous Osteochondral Mosaicplasty for the Treatment of Full-Thickness Defects of Weight-Bearing Joints

    Journal of Bone and Joint Surgery (American) · 2003 · cited 1,008 times · PubMed

    A decade of experience with autologous osteochondral mosaicplasty shows 79-94% good-to-excellent outcomes across knee, patellar, and talar defects with low donor-site morbidity, supporting it as a viable option for focal cartilage defects.

  3. Articular cartilage defects in 1,000 knee arthroscopies

    Arthroscopy · 2002 · cited 942 times · PubMed

    Among 1,000 consecutive knee arthroscopies, 61% showed chondral/osteochondral lesions and 19% had focal defects, with only 5–7% meeting criteria (size, age) for cartilage repair surgery.

  4. Osteochondral Lesions of the Talus: Localization and Morphologic Data from 424 Patients Using a Novel Anatomical Grid Scheme

    Foot & Ankle International · 2007 · cited 455 times · PubMed

    Osteochondral talar lesions most commonly occur in the medial dome at the equator; medial lesions are larger and deeper than lateral lesions with different treatment implications.

  5. Acute Patellar Dislocation in Children: Incidence and Associated Osteochondral Fractures

    Journal of Pediatric Orthopaedics · 1994 · cited 437 times · PubMed

    In a prospective Finnish cohort, acute pediatric patellar dislocation had an annual incidence of 43/100,000 and caused osteochondral fractures in 39% of knees, mostly after spontaneous relocation.

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