This week in Orthopaedic Oncology

Jun 29 – Jul 5, 2026 · 4 new studies, 3 reviews · Orthopaedic Oncology archive · All weeks

The new Orthopaedic Oncology research The Reduction sent the week of Jun 29 – Jul 5, 2026, with the week’s most recent reviews, each with a one-line summary.

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New research

  1. LL-37 inhibits osteosarcoma progression by suppressing SQLE-mediated cholesterol synthesis via the PTEN/AKT/mTOR pathway.

    Journal of Bone Oncology · Aug 2026 · PubMed

    LL-37 peptide inhibits osteosarcoma through PTEN/AKT/mTOR pathway targeting cholesterol synthesis, offering promising therapeutic potential.

  2. Phosphaturic Mesenchymal Tumour of the Soft Tissue in the Finger Presenting without Tumour-Induced Osteomalacia: A Case Report.

    Journal of Hand Surgery (Asian-Pacific) · Aug 2026 · PubMed

    Phosphaturic mesenchymal tumors can present in atypical locations like fingers without tumor-induced osteomalacia; immunohistochemistry confirms diagnosis and marginal excision prevents recurrence.

  3. Frailty is a Vital Tool for Predicting Outcomes Following Prophylactic Femur Fixation.

    Journal of the American Academy of Orthopaedic Surgeons · Jun 23 2026 · PubMed

    Preoperative frailty, particularly the revised Risk Analysis Index, independently predicts mortality and morbidity in patients undergoing prophylactic femur fixation.

  4. Decompression surgery with intraoperative vertebroplasty: a reduced invasiveness treatment strategy for aggressive vertebral hemangiomas.

    European Spine Journal · Jun 05 2026 · PubMed

    Decompression with intraoperative vertebroplasty safely treated aggressive vertebral hemangiomas with reduced blood loss and low recurrence.

Recent reviews

  1. The role of molecular pathology in soft tissue tumor diagnosis: what the radiologist needs to know.

    Skeletal Radiology · Sep 2025 · PubMed

    Molecular pathology enhances soft tissue sarcoma diagnosis and classification; MRI correlation guides clinicians on genetic testing.

  2. Risk of Malignant Transformation of Giant Cell Tumors of Bone Is 8 Times Lower with Megavoltage vs. Orthovoltage Radiation Therapy.

    Sarcoma · 2022 · PubMed

    Megavoltage radiotherapy reduced malignant transformation risk in giant cell tumors 8-fold compared with orthovoltage, supporting modern RT for inoperable cases.

  3. Separation surgery for metastatic epidural spinal cord compression: A qualitative review.

    Journal of Bone Oncology · Dec 2020 · PubMed

    Separation surgery combined with stereotactic body radiation therapy for metastatic epidural cord compression achieves good local control while reducing surgical morbidity.

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